The story of One Punch Man follows Saitama, and the narrative is quite unique in the sense that the main character doesn't need to grow stronger since he already exists at the highest possible levels of power. Because of this, he earned the titular title of being the man who can defeat just about any foe with a single punch.
As such, none of the villains that he has faced have ever truly been much of a challenge for him, except for Cosmic Garou. This form of the Hero Hunter received astronomical strength that allowed him to rival Saitama for a time, making him the strongest foe in One Punch Man so far. However, there are some others that can match him, so let's take a look at who they are.
Just as a trend, Boros was someone who broke away from the norm that Shonen anime series typically follow, which is of introducing an immensely powerful villain early on who was way stronger than many who came later. Even receiving praise from Saitama himself, Boros is cemented in history as one of the fiercest combatants in the universe.
As such, his strength warranted the Caped Baldy to actually put in more effort than he ever had before to put him down, though this was still merely a single punch. If given enough training time, it's quite conceivable for Boros to have risen to Cosmic Garou's level, especially when considering how a member of his race is a part of Blast's mysterious cosmic team.
The Monster Association arc remains the highest point of the One Punch Man story, and the longer it went on, the greater the stakes became. At the very end, the heroes were in for their toughest time, as the most powerful monsters were standing against them and were led by the most powerful monster on Earth at the time; Psykorochi.
Born from the merger of the incredibly powerful psychic Psykos and the unparalleled strength of Orochi, the resulting calamity was impossibly strong, enough to deal out catastrophic psychic and physical attacks simultaneously. Though the merger was defeated by Tatsumaki, Psykorochi may have grown to rival Cosmic Garou if more power was taken from God.
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The S-Class heroes are the most powerful and revered in the entire setting, and among them, Blast sits at the top of the list as the greatest hero in the entire world. As such, his strength definitely reflects this, and although he hasn't been shown in a full combat situation, he proved this when Cosmic Garou and Saitama clashed.
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