Players who wonder if they can beat Brencis in the Prologue of The Blood of Dawnwalker should know that, yes, you can indeed beat Brencis in the Prologue. However, this takes a lot of effort and multiple attempts, since you'll be under-leveled and don't have enough skills unlocked. Additionally, you won't get any special ending. If anything, you'll miss out on the minor endings that you can get by meeting companions in Vale Sangora.
This article contains spoilers about the endings of The Blood of Dawnwalker. Proceed with caution.
Yes, you can beat Brencis in the Prologue of The Blood of Dawnwalker. In fact, the first phase of Brencis's boss fight is pretty easy, especially if you play on Story difficulty. However, the second phase is a different story.
Since Coen will be under-leveled, his weapon barely does any damage to Brencis, yet Brencis can one-shot Coen, meaning you need to have a perfect no-hit battle while dealing minuscule damage, greatly extending the combat duration.
After you beat Brencis, the game will end normally, with him being in disbelief. There are barely any unique lines compared to beating him normally outside the Prologue. For example, he would say something like, "I just turned you." Brencis will also mention that while he took your family away, he took a little time to "get to know them." Both remarks don't exist outside the Prologue.
However, the fate of your family remains the same as in most The Blood of Dawnwalker endings. If your mom survives the Mass (which you can do by brewing the medicine correctly), then your entire family will stay alive. Additionally, despite never dabbling in witchcraft, Coen's ending remains as if he did it.
The greatest effect of beating Brencis in the Prologue is the lack of minor endings. Since you won't travel or meet with companions such as Anca, Lacra, Ocha, Vicho, Crake, and so on, you won't get to witness their minor endings. Since The Blood of Dawnwalker is a narrative game, you'd miss out on a lot if you decide to end the game by beating Brencis in the Prologue.
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