In The Witcher 3's main quest, you will eventually take a boat and sail to the Isle of Mists; you'll receive a warning: "You are nearing a crucial point in the game's story. It is recommended that you save your game in a Manual Save Slot now." It's recommended that you turn back and avoid doing The Isle of Mists quest until you've first completed the side quests shown below. The Isle of Mists is a crucial cutoff point for many side quests in The Witcher 3, and you can find a full list of them below.
Investigate Ciri's room during her stay at Crow's Perch.
The Fall of the House of Reardon [MARK]
Found on Lindenvale's notice board, Velen
Explore an abandoned manor to find Letho (if you spared him in the simulated save).
Help Letho, a witcher from a previous adventure.
Help Keira Metz retrieve a magical lamp from an elven mage.
An Invitation from Keira Metz [MARK]
سەرچاوەی فەرمی بە زمانی ئینگلیزی: https://gamerant.com/witcher-3-everything-to-do-before-isle-of-mists/